Tadalafil works by inhibiting the PDE5 enzyme. This enzyme is involved in the breakdown of cyclic guanosine monophosphate (cGMP), a substance that aids in the relaxation of smooth muscle in the penis. Tadalafil raises cGMP levels by inhibiting PDE5, which causes smooth muscle relaxation in the penile blood vessels. This relaxation enhances blood flow to the penis during sexual stimulation, facilitating an erection. Tadalafil has a longer duration of action than other ED medications. The effects of Vidalista 60 mg may last up to 36 hours. Because of its longer duration of action, it is sometimes referred to as "the weekend pill."