Small double-stranded RNA molecules, or siRNA, are the mediating agents of RNA interference in animals. Single-gene therapies, or siRNAs, are a promising new class of medicines that can be employed as tools to research single gene activity both in vivo and in vitro. Viral and non-viral delivery methods, including as peptides, polymers, and lipids, are the two types of siRNA delivery systems. Several investigations utilizing plasmid-encoded or synthetically produced endogenously expressed siRNA demonstrate the antiviral activity of siRNA against a range of viruses, including SARS-CoV. The documented siRNA agents exhibit no toxicity in the Rhesus macaque model and are effective in treating SARS infections both therapeutically and prophylactically.

For more: siRNA for Treatment of SARS-CoV-2