Only one week of preseason stands in the way of real NFL games. That's right; the 2021 season is finally upon us. And boy, is the Week 1 slate loaded with spicy matchups. Who plays who on Opening Weekend, you ask? And where can you catch the official return of football? We've got you covered below with a rundown of all 16 Week 1 matchups, from Thursday to Monday night, including TV channels and things to know for each:Game: at Kickoff: 8:20 p.m. ETTV: NBCThe official 2021 kickoff, this marks the anticipated return of Cowboys quarterback , who's coming off both ankle and shoulder injuries. Prescott's first mi sion: Survive Todd Bowlers' ferocious defensive front, and out-duel the reigning Super Bowl MVP, , on the road.Game: at Kickoff: 1 p.m. ETTV: CBS ()The Urban Meyer-Trevor Lawrence regime will make its real debut against maybe Grant Hill Jersey the most beatable opponent in all of the NFL. Absent a last-minute resolution in legal dispute, the Texans will open with and a bunch of veteran castoffs in their lineup.Game: at WashingtonKickoff:1 p.m. ETTV:CBS () bid for second-year MVP honors starts against Ron Rivera's defense, one of the most well-rounded in the league. , meanwhile, gets his first crack at Ben Wallace Jersey owning a full-time starting quarterback job against Brandon Staley's own "D." Game: at Kickoff:1 p.m. ETTV: FOXIndy would like nothing more than to open at home with both QB and All-Pro guard in the lineup. Even then, will there have been enough time for the Colts' new pieces to build chemistry, let alone stave off and Seattle's motivated offensive staff?Game: at Kickoff:1 p.m. ETTV:CBS ()Robert Saleh will make his debut as Jets coach here, but the real focus will be the QB battle, with getting an instant crack at revenge on New York and the super-armed looking to prove he's already a superior talent in the Big Apple.Game: at Kickoff:1 p.m. ETTV: FOXBengals Nation is hyped for the anticipated return of QB , who now has more weapons to play with. But Mike Zimmer is no stranger to Cincy, and he's rolling out a restocked veteran "D" featuring , and . This one could either be a slugfest or a shootout, with and set to test the Bengals' own remade defense. Game: at Kickoff:1 p.m. ETTV:CBS () and entered the NFL together, and here, they'll debut for new teams for the first time in their respective careers. Tenne see is far more bruising in its approach, but play-extending legs could make Arizona an upset candidate.Game: at Kickoff:1 p.m. ETTV: FOXWhether it's incumbent or rookie under center, the 49ers will hit Motown as big favorites now Sekou Doumbouya Jersey that they're healthy again. , meanwhile, will just be hoping to stay upright in his first real snaps as outcast-turned-Lions QB.Game: at Kickoff:1 p.m. ETTV:CBS ()A dark-horse AFC Championship preview? is reportedly fitter and feisty for what could be his last year, but Pittsburgh's scrapyard front might have its hands full against Sean McDermott's "D." Oh, and , too. Game: at Kickoff:1 p.m. ETTV: FOX will look to kick his career into a new gear under new coach Arthur Smith, but the Eagles might be more intriguing: The peppy Nick Sirianni is debuting in place of Doug Pederson, along with the poised but unproven at QB.Game: at Kickoff:4:25 p.m. ETTV:CBS ()Talk about a big test right out of the gate ... for both sides! Maybe the matchup of the week, this playoff rematch pits , and against , and . And that's only a small fraction of the big names set to square off at Arrowhead. Killian Hayes Jersey This may give us an early, if premature, indication of whether Cleveland is still for real.Game: at Kickoff:4:25 p.m. ETTV: FOXVic Fangio's seat may be hot, but he'll roll into New Jersey with a safety net at QB () and an improved "D" welcoming back . For the Giants, this is all about seeing take a legitimate step with weapons around him. Game: at Kickoff:4:25 p.m. ETTV:CBS ()Like the 49ers, the Pats will draw eyes regardle s of whether it's the vet () or the hotshot rookie () at QB. Miami might be the AFC East's No. 2 contender, though, if can capitalize on his more explosive outlets.Game: at RamsKickoff:8:20 p.m. ETTV: NBCAll Wayne Ellington Jersey of Windy City wants rookie under center, but the Bears will roll with for the prime-time meeting with and Co. Does that spell trouble? You be the judge. L.A. is also debuting , who will replace the departed Jared Goff while throwing to the likes of , and . Prepare for the fireworks.Game: at Kickoff:8:15 p.m. ETTV:ESPNLas Vegas is arguably a forgotten team in the West, where the Chiefs and Chargers are playoff favorites and the Broncos at least boast a stingy defense. Their one saving grace for Week 1: They get to stay home. Other than that, they'll be hoping and the run-heavy Ravens are experiencing an unprecedented level of jet lag while kicking off a hopeful title run. Who will win the Championship?