Custom synthesis Available Apoptosis Library Chemical Structure: MIK665 CAS No.: 1799631-75-6 聽 MIK665(MIK 665, S 64315, S64315) Catalog No.: URK-V595聽聽Only Used For Lab. MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities. 聽 Biological Activity MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities. MIK665 (S-64315) binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival. 聽 Physicochemical Properties M.Wt875.413 FormulaC47H44ClFN6O6S CAS No.1799631-75-6 StorageSolide Powder -20 掳C 3years; 4掳C 2yearsIn Solvent -80掳C 6 Months -20掳C 1 Months Solubility10 mM in DMSO Chemical Name(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid 聽 References 1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098. URK-V595_COA URK-V595_SDS URK-V595_TDS 聽 Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use 聽Custom synthesis Available Apoptosis Library website:http://www.ureiko-chem.com/inhibitors-agonists/apoptosis-library/
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