"Recently, NPs have been extensively explored in diagnostic and therapeutic contexts, with potential applications and various advantages such as improving targeting by modifying ligands and protecting their cargo from inactivation or degradation before target delivery in vivo. However, when synthetic NPs are introduced to in vivo applications, they are easily considered intruders by the innate immune system and readily cleared by the reticuloendothelial system (RES), thus quickly losing their functionalities," cited from https://cellface-conjugate.creative-biolabs.com/cell-membrane-coating-technology.htm.