An engineered Fc protein (https://adcc.creative-biolabs.com/adcc-cdc-antibody-process-development.htm) backbone is commonly used to improve the ability of IgG1 antibodies to trigger CDC process. It is also known that some key amino acids at CH2 domain can bind to the component C1q.
An engineered Fc protein (https://adcc.creative-biolabs.com/adcc-cdc-antibody-process-development.htm) backbone is commonly used to improve the ability of IgG1 antibodies to trigger CDC process. It is also known that some key amino acids at CH2 domain can bind to the component C1q.
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