Tadalafil works by inhibiting the PDE5 enzyme. This enzyme is involved in the breakdown of cyclic guanosine monophosphate (cGMP), a substance that aids in the relaxation of smooth muscle in the penis. Tadalafil raises cGMP levels by inhibiting PDE5, which causes smooth muscle relaxation in the penile blood vessels. This relaxation enhances blood flow to the penis during sexual stimulation,...
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